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Perhaps they need one more name change, since they are not always that interested in the Science part of their name.
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The most common side effects of this medication are pain, redness, and swelling at the injection site and increased liver enzyme levels.
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Treatment of Prostate Cancer: cells normally grow faster in the presence of testosterone.
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Indeed, compared with castration alone, CAB with flutamide is associated with an increased incidence of gastrointestinal disorders and hepatotoxicity, whereas CAB using nilutamide is associated with an increased incidence of visual disorders.
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Residual tissue androgens are implicated in driving the majority of mechanisms whereby persistent AR-mediated signaling drives castration resistant disease.
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The initial efforts to develop steroidal SARMs, based on modifications of the testosterone molecule, date back to the 1940s.
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Civantos et al published the largest series on the pathology of androgen deprivation therapy for prostate cancer, and in the series of 173 patients who were treated with a luteinizing hormone-releasing hormone (LHRH) analogue and an antiandrogen (AA) prior to radical prostatectomy (RP), atrophy was observed in benign and malignant tissue.
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Serum SHBG levels tend to increase with age, thereby reducing free testosterone levels, which may result in sexual dysfunction.
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Previous antiandrogen therapy and concurrent use of glucocorticoids were permitted but not required.
Also shown is the wild-type W741 residue (white) to illustrate a possible steric clash between tryptophan and the B-ring of bicalutamide.
1 CFTR variants are categorized into five classes of mutations that affect how the CFTR protein is made and, ultimately, how this disorder is treated.
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The institutional review board at each medical center approved the follow-up study, and all patients provided written informed consent.
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Details of adverse events occurring during the trial were elicited by open questioning.
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Two patients in the LHRH-A monotherapy group withdrew from the study before commencing treatment (because of deterioration of performance status and failure to attend a hospital visit, respectively).
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In accordance, the efficacy of bicalutamide has been found to be at least equivalent to flutamide in the treatment of prostate cancer in a direct head-to-head comparison, and indications of superior efficacy, including significantly greater relative decreases and increases in levels of and testosterone, respectively, were observed.
Although specific testosterone data are not available, it does suggest that ineffective or inconsistent testosterone suppression by LHRH analogues (masked by the addition of a nonsteroidal antiandrogen) might be an explanation.
Treatments are given following a medical diagnosis and can be used alongside conventional cancer treatments such as cancer drugs or radiotherapy.
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QoL was assessed as a secondary endpoint in this study using the Japanese version of the Functional Assessment of Cancer Therapy-Prostate questionnaire.
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