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Importance of advising patients that use of multiple daily doses of the drug for an extended period of time may increase the risk of fractures of the hip, wrist, or spine.

Especially confounding by indication, an important bias in pharmacoepidemiologic studies, is diminished by using propensity score matching by calculating the probability to be exposed to a treatment or not.

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Because pantoprazole sodium was not shown to be effective in the randomized, placebo-controlled study in this age group, the use of pantoprazole sodium for treatment of symptomatic GERD in infants less than 1 year of age is not indicated.

Conversely, there are rare cases of angioedema, anaphylaxis and stern dermatologic reactions have been linked with the use pantoprazole.

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Following screening laboratories and a full chart review, 23 patients were found to be eligible and were randomized into the study.

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These elements do not show up when therapies are compared against sham treatments, because they are present in both arms of a trial.

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Erosive esophagitis healing rates in the 221 women treated with Pantoprazole Sodium Delayed-Release Tablets in US clinical trials were similar to those found in men.

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